ICNA02158809

ICNA0215880920EA 147 EUR
ICNA0215880920 ICNA0215880980
ICNA02158809
Ebselen is a novel selenium-containing anti-flammatory agent.

Ebselen inhibits 5-LO, CO, NADPH oxidase, and protein kinase C. It is a potent antioxidant. It possesses a unique glutathione peroxidase-like activity. It is also shown to be an inhibitor of free radical induced apoptosis and neuroprotective agent.

Ebselen inhibits mammalian lipoxygenases in the absence of thiol groups, and glutathione S-transferase and papain via the interaction with cysteine residues. Also inhibits indoleamine 2,3-dioxygenase by covalently modifying a cysteine residue, the effect being reversible with dithiothreitol. Inhibits oxidation of low density lipoproteins (LDL).

Soluble in DMSO (25 mg/ml) and ethanol (10 mg/ml). Also soluble in chloroform (19,60 - 20,40 mg/ml - clear yellow solution).
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