Capto™ adhere is a multimodal anion exchanger for intermediate purification and polishing of monoclonal antibodies after the Protein A capture step, giving the possibility to design a two-step chromatographic downstream process.
- High capacity and productivity in flow-through mode
- Wide operational window of pH and conductivity
- Two-step chromatographic process with protein A affinity, saves time and cuts operating costs
It can remove key contaminants such as DNA, host cell proteins (HCP), leached protein A, dimers and larger aggregates, and viruses in a single step. Together with a Protein A capture step, like MabSelect SuRe™, Capto™ adhere allows the design of a two-step chromatographic process for monoclonal antibodies. For optimal performance, screening/optimisation of loading conditions is recommended, preferably using modern high throughput process development tools, such as PreDictor™ 96-well filter plates.