Anti-TIGIT Mouse Monoclonal Antibody (APC (Allophycocyanin)) [clone: 1G9]

Lieferant: Tonbo Biosciences

20-1421-U025EA 65.8 EUR
20-1421-U025 20-1421-U100
Anti-TIGIT Mouse Monoclonal Antibody (APC (Allophycocyanin)) [clone: 1G9]
Antikörper
The 1G9 antibody reacts with mouse TIGIT (T cell Ig and ITIM domain), a 26 kDa member of the CD28 receptor family which is reported to regulate T cell receptor (TCR) activation. Within the CD28 family of receptors there are those which have co-stimulatory activity, such as CD28 and CTLA-4, as well as more recently identified receptors like TIGIT which are proposed to provide co-inhibitory signals. TIGIT is expressed and upregulated on activated T cells, and is also expressed on memory and regulatory T cells. Upon engagement by its ligands, CD112 and CD155, TIGIT signaling inhibits T cell proliferation and suppresses T cell responses, without triggering cell deletion. A second inhibitory effect of TIGIT signaling is the generation of immunoregulatory dendritic cells, which secrete IL-10 and TGF-beta to further inhibit T cell function.

The 1G9 antibody may be used for flow cytometric analysis of TIGIT, which is expressed at very high levels on T regulatory cells (Tregs) and activated conventional T cells, as well as memory T cells and NK cells.

Type: Primary
Antigen: TIGIT (T cell immunoreceptor with Ig and ITIM domains)
Clonality: monoclonal
Clone: 1G9
Conjugation: APC (Allophycocyanin)
Epitope:
Host: Mouse
Isotype: IgG1 Kappa
Reactivity: Mouse
Bestellen

Learn more

About VWR

Avantor is a vertically integrated, global supplier of discovery-to-delivery solutions for...

Mehr About VWR