Anti-CTLA4 Armenian Hamster Monoclonal Antibody (APC (Allophycocyanin)) [clone: UC10-4F10-11]

Lieferant: Tonbo Biosciences

20-1522-U100EA 151 EUR
20-1522-U100 20-1522-U025
Anti-CTLA4 Armenian Hamster Monoclonal Antibody (APC (Allophycocyanin)) [clone: UC10-4F10-11]
Antikörper
The UC10-4F10-11 antibody is specific for mouse CD152, commonly known as CTLA-4, a 33-37 kDa protein expressed as a homodimer on the surface of activated T and B cells, and on thymocytes. CTLA-4 is structurally similar, yet functionally disparate, to the T cell co-stimulatory molecule CD28. Both CTLA-4 and CD28 interact with the co-stimulatory molecules CD80 (B7-1) and CD86 (B7-2) on antigen-presenting cells, with CTLA-4 displaying a higher avidity than CD28. While CD28 typically delivers a potent co-stimulatory signal in support of T cell activation, CTLA-4 appears to act as a negative regulator of T cell activation and may contribute to the suppressor function of Treg cells.

Type: Primary
Antigen: CTLA4 (cytotoxic T-lymphocyte-associated protein 4)
Clonality: monoclonal
Clone: UC10-4F10-11
Conjugation: APC (Allophycocyanin)
Epitope:
Host: Armenian Hamster
Isotype: IgG1 Kappa
Reactivity: Mouse
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