Anti-KLRG1 Mouse Monoclonal Antibody (APC (Allophycocyanin)) [clone: 2F1]

Lieferant: Tonbo Biosciences

20-5893-U100EA 146 EUR
20-5893-U100 20-5893-U025
Anti-KLRG1 Mouse Monoclonal Antibody (APC (Allophycocyanin)) [clone: 2F1]
Antikörper
The 2F1 antibody reacts with mouse KLRG1 (Killer cell Lectin-like Receptor G1). This 30-38 kDa homodimeric receptor may be expressed by activated, mature NK cells and by effector/memory T cells, with potentially different roles in each cell type. KLRG1 can regulate, in an inhibitory fashion, the development and effector functions of NK cells, and is often cited as a senescence or terminal differentiation marker for T cells. Ligands for KLRG1 include members of the cadherin family of adhesion molecules, specifically N-Cadherin, E-Cadherin, and R-Cadherin. These interactions may induce bidirectional, immunosuppressive signaling in both KLRG- and Cadherin-expressing cells. A more recently identified role for KLRG1-Cadherin signaling in tissue organization, e.g. in cardiac angiogenesis, expands the function of these interactions beyond immunosuppression of immune cells. (Bouchentouf et al. 2010. J. Immunol. 185: 7014-7025).

Type: Primary
Antigen: KLRG1 (killer cell lectin-like receptor subfamily G, member 1)
Clonality: monoclonal
Clone: 2F1
Conjugation: APC (Allophycocyanin)
Epitope:
Host: Mouse
Isotype: IgG
Reactivity: Mouse
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