Anti-CD8A Mouse Monoclonal Antibody (APC (Allophycocyanin))/Cy7®) [clone: RPA-T8]

Lieferant: Tonbo Biosciences

25-0088-T025EA 63.9 EUR
25-0088-T025 25-0088-T100
Anti-CD8A Mouse Monoclonal Antibody (APC (Allophycocyanin))/Cy7®) [clone: RPA-T8]
Antikörper
The RPA-T8 antibody is specific for the 32-34 kDa alpha chain of human CD8, known as CD8a or CD8 alpha. CD8a can form a homodimer (CD8 alpha-alpha), but is more commonly expressed as a heterodimer with a second chain known as CD8b or CD8 beta. CD8 acts as a co-receptor for antigen recognition and subsequent T cell activation that is initiated upon binding of the T cell receptor (TCR) to antigen-bearing MHC Class I molecules. The cytoplasmic domains of CD8 provide binding sites for the tyrosine kinase lck, facilitating intracellular signaling events that lead to T cell activation, development, and cytotoxic effector functions. CD8+ cytotoxic T cells (CTLs) play an important role in inducing cell death of tumor cells, as well as cells infected by virus, bacteria or parasites.

Type: Primary
Antigen: CD8A (CD8a molecule)
Clonality: monoclonal
Clone: RPA-T8
Conjugation: APC (Allophycocyanin)/Cy7®
Epitope:
Host: Mouse
Isotype: IgG1 Kappa
Reactivity:
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