Anti-CD28 Mouse Monoclonal Antibody [clone: 37.51]

Lieferant: Tonbo Biosciences

40-0281-U500EA 134 EUR
40-0281-U500 40-0281-M001 40-0281-U100
Anti-CD28 Mouse Monoclonal Antibody [clone: 37.51]
The 37.51 antibody reacts with mouse CD28, a 45 kDa glycoprotein which acts as a co-stimulatory receptor in support of the T cell receptor (TCR). CD28 exists as a homodimer with specificity for two known ligands, known as B7-1 (CD80) and B7-2 (CD86), expressed on activated B cells and antigen-presenting cells. These ligands trigger CD28 signaling in concert with TCR activation to drive T cell proliferation, induce high-level expression of IL-2, impart resistance to apoptosis, and enhance T cell cytotoxicity. The interaction / co-stimulatory signaling between the B7 ligands and CD28 provides crucial communication between T cells and B cells or APCs to coordinate the adaptive immune response. Other members of the CD28 family of co-stimulatory receptors include CTLA-4 (CD152), PD-1 (CD279), ICOS and BTLA.

Type: Primary
Antigen: CD28 (CD28 molecule)
Clonality: monoclonal
Clone: 37.51
Conjugation: unconjugated
Host: Mouse
Isotype: IgG
Reactivity: Mouse

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