Anti-CSF1R Rat monoclonal antibody [clone: AFS98]

Lieferant: Tonbo Biosciences

40-1152-U100EA 127 EUR
40-1152-U100 40-1152-U500
Anti-CSF1R Rat monoclonal antibody [clone: AFS98]
The AFS98 antibody is specific for mouse CD115, also known as Colony-Stimulating Factor-1 Receptor (CSF-1R), a 145 kDa receptor from the PDGF receptor family. Receptor activation by the ligands IL-34 or CSF-1 (M-CSF) occurs via homodimerization of CD115 and subsequent tyrosine phosphorylation and ubiquitination of intracellular domains. CD115 signaling promotes differentiation of myeloid precursors, as well as the continued regulation of proliferation, survival and function of mononuclear phagocytes, dendritic cells and osteoclasts. While IL-34 and CSF-1 may induce similar cellular responses, they are differentially expressed and as such exert complimentary actions via CD115.

Type: Primary
Antigen: CSF1R (colony stimulating factor 1 receptor)
Clonality: monoclonal
Clone: AFS98
Conjugation: unconjugated
Host: Rat
Isotype: IgG2a Kappa
Reactivity: Mouse

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