Anti-LRRC32 Mouse Monoclonal Antibody (PE (Phycoerythrin)) [clone: GARP5]

Lieferant: Tonbo Biosciences

50-9882-T100EA 214 EUR
50-9882-T100 50-9882-T025
Anti-LRRC32 Mouse Monoclonal Antibody (PE (Phycoerythrin)) [clone: GARP5]
The GARP5 antibody reacts with human GARP, also known as LRRC32 or Garpin, an 80 kDa transmembrane protein which acts as a receptor for the latent form of TGF-beta 1 (pro-TGF-beta), preventing its secretion. Specifically, GARP is reported to associate with the pro-domain of TGF-beta 1, known as latency-associated peptide (LAP), which must be cleaved to release the biologically active cytokine. The putative role of GARP in sequestering the TGF-beta is important for regulating its activity, as TGF-beta signaling is involved in development and function of Th17, Treg and many other immune cell types. GARP expression has been shown on platelets and at high levels on Foxp3+ Treg cells, where it is proposed to be a phenotypic identifier for activated human Treg cells.

Type: Primary
Antigen: LRRC32 (leucine rich repeat containing 32)
Clonality: monoclonal
Clone: GARP5
Conjugation: PE (Phycoerythrin)
Host: Mouse
Isotype: IgG1
Reactivity: Human

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