Anti-CD3E Armenian Hamster Monoclonal Antibody (PE (Phycoerythrin)/Cy5®) [clone: 145-2C11]

Lieferant: Tonbo Biosciences

55-0031-U100EA 100 EUR
55-0031-U100 55-0031-U025
Anti-CD3E Armenian Hamster Monoclonal Antibody (PE (Phycoerythrin)/Cy5®) [clone: 145-2C11]
Antikörper
The 145-2C11 antibody is specific for mouse CD3e, also known as CD3 epsilon, a 20 kDa subunit of the T cell receptor complex, along with CD3 gamma and CD3 delta. These integral membrane protein chains assemble with additional chains of the T cell receptor (TCR), as well as CD3 zeta chain, to form the T cell receptor – CD3 complex. Together with co-receptors CD4 or CD8, the complex serves to recognize antigens bound to MHC molecules on antigen-presenting cells. Such interactions promote T cell receptor signaling (T cell activation) and can result in a number of cellular responses including proliferation, differentiation, production of cytokines or activation-induced cell death. CD3 is differentially expressed during thymocyte-to-T cell development and on all mature T cells.

The 145-2C11 antibody is a widely used phenotypic marker for mouse T cells. In addition, binding of 145-2C11 antibody to CD3e can induce cell activation (use format . A recent publication of the crystal structure of a murine CD3e-mitogenic antibody complex provides further insight into the action of commonly used agonist antibodies (Fernandes, R.A. et al. 2012. J. Biol. Chem. 287: 13324-13335).

Type: Primary
Antigen: CD3E (CD3e molecule, epsilon (CD3-TCR complex))
Clonality: monoclonal
Clone: 145-2C11
Conjugation: PE (Phycoerythrin)/Cy5®
Epitope:
Host: Armenian Hamster
Isotype: IgG
Reactivity: Mouse
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