Anti-CD8A Rat Monoclonal Antibody (Peridinin Chlorophyll/Cy5.5®) [clone: 2.43]

Lieferant: Tonbo Biosciences

65-1886-U100EA 185 EUR
65-1886-U100 65-1886-U025
Anti-CD8A Rat Monoclonal Antibody (Peridinin Chlorophyll/Cy5.5®) [clone: 2.43]
The 2.43 antibody reacts with the 32-34 kDa alpha subunit of mouse CD8, known as CD8a or CD8 alpha. CD8a can form a homodimer (CD8 alpha-alpha), but is more commonly expressed as a heterodimer with a second chain known as CD8b or CD8 beta. CD8 acts as a co-receptor in antigen recognition and subsequent T cell activation induced by binding of the T cell receptor (TCR) to antigen-bearing MHC Class I molecules. The cytoplasmic domains of CD8 provide binding sites for the tyrosine kinase lck and facilitate intracellular signaling events that lead to T cell activation, development, and cytotoxic effector functions. CD8+ cytotoxic T cells (CTLs) play an important role in inducing cell death in tumor cells, as well as in cells infected by virus, bacteria or parasites.

Type: Primary
Antigen: CD8A (CD8a molecule)
Clonality: monoclonal
Clone: 2.43
Conjugation: Peridinin Chlorophyll/Cy5.5®
Host: Rat
Isotype: IgG2b
Reactivity: Mouse

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