Anti-KIT Rat Monoclonal Antibody [clone: ACK2]

Lieferant: Tonbo Biosciences

70-1172-U100EA 75.1 EUR
70-1172-U100
Anti-KIT Rat Monoclonal Antibody [clone: ACK2]
Antikörper
The ACK2 antibody is specific for CD117, also called c-Kit, a 145 kDa cytokine receptor important in the development of hematopoietic stem cells, in oogenesis, and for functional activity of immune cells such as NK and mast cells. c-Kit binds to a ligand known as stem cell factor (SCF), or alternatively as mast cell growth factor. Ligand binding promotes the activation (dimerization) and subsequent tyrosine kinase activity of the c-Kit receptor and triggers key survival, expansion and maturation signals during hematopoietic progenitor cell development. Conversely, shedding of extracellular domain of c-Kit receptor is reported to induce inactivation or apoptosis within these cells. The survival signaling activity of c-Kit confers a proto-oncogenic attribute to the receptor, as overexpression or mutations in this protein are associated with tumor development.

Type: Primary
Antigen: KIT (v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog)
Clonality: monoclonal
Clone: ACK2
Conjugation: unconjugated
Epitope:
Host: Rat
Isotype: IgG2b Kappa
Reactivity: Mouse, Rat
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