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Anti-LYN Mouse Monoclonal Antibody [clone: 2H8D7]

Lieferant: Thermo Scientific
MA5-15329 targets LYN in WB applications and shows reactivity with Human samples. The MA5-15329 immunogen is purified recombinant fragment of LYN expressed in E. Coli. MA5-15329 detects LYN which has a predicted molecular weight of approximately 56kDa. Lyn (also known as p53/56 Lyn) is a membrane-associated protein tyrosine kinase (PTK) mostly expressed in hemopoietic cells which is important in cellular signaling. It contains an SH2 and SH3 domain and has been found to be cleaved after activation of caspases in apoptosis. A member of the Src family of PTKs, there are two known isoforms for Lyn which plays an indispensable role in the Fc epsilon RI (Fcer1) and the B-cell IgM receptor signaling pathway and is essential for Syk activation and Lat phosphorylation after Fcer1 aggregation and can also phosphor-ylate Tec on multiple residues. Lyn can also be regulated by IL-2 and IL-3.Lyn is a member of the src family of non-receptor protein tyrosine kinases that is predominantly expressed in haematopoietic tissues. Like all members of the src family, lyn is thought to participate in signal transduction from cell surface receptors that lack intrinsic tyrosine kinase activity. It is associated with a number of cell surface receptors including the B cell antigen receptor and immunoglobulin E receptor (FceRI).

Type: Primary
Antigen: LYN
Clonality: Monoclonal
Clone: 2H8D7
Conjugation: Unconjugated
Epitope:
Host: Mouse
Isotype: IgG2b
Reactivity: Human



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100 µL 100 µl PIEAMA515329 Blocked
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TECHNISCHE DATEN

Antigen symbol LYN
Antigen name Tyrosine-protein kinase Lyn
Reaktivität Human
Konjugation Unconjugated
Klonalität Monoclonal
Antikörper Typ Primary
Clone 2H8D7
Wirt Mouse
Isotyp IgG2b
Western Blot Yes
Antigen synonyms JTK8, LYN, FLJ26625
Gene ID 4067
Format ascites
Immunogen Purified recombinant fragment of LYN expressed in E. Coli.
Form Liquid
Storage Buffer ascites, 0.03% sodium azide
Lagertemperatur Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Transporttemperatur Ice
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