Anti-HER2 Mouse Monoclonal Antibody [clone: 9B9D8]

Lieferant: Thermo Fisher Scientific
PIEAMA515332EA 0 EUR
PIEAMA515332
Anti-HER2 Mouse Monoclonal Antibody [clone: 9B9D8]
Antikörper
MA5-15332 targets HER-2 in IHC and WB applications and shows reactivity with Human samples. The MA5-15332 immunogen is purified recombinant fragment of HER-2 expressed in E. Coli. This gene encodes a member of the epidermal growth factor (EGF) receptor family of receptor tyrosine kinases. This protein has no ligand binding domain of its own and therefore cannot bind growth factors. However, it does bind tightly to other ligand-bound EGF receptor family members to form a heterodimer, stabilizing ligand binding and enhancing kinase-mediated activation of downstream signalling pathways, such as those involving mitogen-activated protein kinase and phosphatidylinositol-3 kinase. Allelic variations at amino acid positions 654 and 655 of isoform a (positions 624 and 625 of isoform b) have been reported, with the most common allele, Ile654/Ile655, shown here. Amplification and/or overexpression of this gene has been reported in numerous cancers, including breast and ovarian tumors. Alternative splicing results in several additional transcript variants, some encoding different isoforms and others that have not been fully characterized.

Type: Primary
Antigen: HER2
Clonality: Monoclonal
Clone: 9B9D8
Conjugation: Unconjugated
Epitope:
Host: Mouse
Isotype: IgG2b
Reactivity: Human
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