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Anti-FGFR4 Mouse Monoclonal Antibody [clone: 4H2B10B2]

Lieferant: Thermo Scientific
MA5-15350 targets FGFR4 in IHC and WB applications and shows reactivity with Human samples. The MA5-15350 immunogen is purified recombinant fragment of FGFR4 expressed in E. Coli. MA5-15350 detects FGFR4 which has a predicted molecular weight of approximately 88kDa. The protein encoded by this gene is a member of the fibroblast growth factor receptor family, where amino acid sequence is highly conserved between members and throughout evolution. FGFR family members differ from one another in their ligand affinities and tissue distribution. A full-length representative protein would consist of an extracellular region, composed of three immunoglobulin-like domains, a single hydrophobic membrane-spanning segment and a cytoplasmic tyrosine kinase domain. The extracellular portion of the protein interacts with fibroblast growth factors, setting in motion a cascade of downstream signals, ultimately influencing mitogenesis and differentiation. The genomic organization of this gene, compared to members 1-3, encompasses 18 exons rather than 19 or 20. Although alternative splicing has been observed, there is no evidence that the C-terminal half of the IgIII domain of this protein varies between three alternate forms, as indicated for members 1-3. This particular family member preferentially binds acidic fibroblast growth factor and, although its specific function is unknown, it is overexpressed in gynecological tumor samples, suggesting a role in breast and ovarian tumorigenesis.

Type: Primary
Antigen: FGFR4
Clonality: Monoclonal
Clone: 4H2B10B2
Conjugation: Unconjugated
Epitope:
Host: Mouse
Isotype: IgG1
Reactivity: Human



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100 µL 100 µl PIEAMA515350 Blocked
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TECHNISCHE DATEN

Antigen symbol FGFR4
Antigen name Fibroblast growth factor receptor 4
Reaktivität Human
Konjugation Unconjugated
Klonalität Monoclonal
Antikörper Typ Primary
Clone 4H2B10B2
Wirt Mouse
Isotyp IgG1
Western Blot Yes
ImmunoChemistry Yes
Antigen synonyms Fibroblast Growth Factor Receptor 4, Fibroblast growth factor receptor 4, TKF, JTK2, MGC20292, FGF Receptor 4
Gene ID 2264
Format ascites
Immunogen Purified recombinant fragment of FGFR4 expressed in E. Coli.
Form Liquid
Storage Buffer ascites, 0.03% sodium azide
Lagertemperatur Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Transporttemperatur Ice
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