Anti-IRS1 Rabbit Polyclonal Antibody

Lieferant: Thermo Fisher Scientific
PIEAPA116927EA 0 EUR
PIEAPA116927
Anti-IRS1 Rabbit Polyclonal Antibody
Antikörper
This antibody does not react with monkey samples. Suggested positive control: Glucose treated pancreatic islets and endogenous protein of pancreatic beta cells (20 ug). IRE1 acts as the sensor of unfolded proteins in the ER that initiates transmittance of the unfolded protein signal from the ER to the nucleus by splicing XBP1 mRNA converting it into a potent unfolded-protein response transcriptional activator. It is a transmembrane protein that has both serine-threonine kinase and endoribonuclease acitvities. Null mutants are viable, but IRE1 is essential for viability under stress conditions that cause unfolded proteins to accumulate in the ER.

Type: Primary
Antigen: IRS1
Clonality: Polyclonal
Clone:
Conjugation: Unconjugated
Epitope:
Host: Rabbit
Isotype: IgG
Reactivity: Rat, Mouse, Human, Rabbit
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