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Anti-LC3A/B Rabbit Polyclonal Antibody

Lieferant: Thermo Scientific

This antibody detects both LC3A and LC3B. In Western blot bands are seen ~17 and 19 kDa. Suggested positive control: human and mouse brain lysate, antigen standard for MAP1LC3B (transient overexpression lysate), mouse brain protein, human brain protein. Autophagy is a process of intracellular bulk degradation in which cytoplasmic components, including organelles, are sequestered within double-membrane vesicles that deliver the contents to the lysosome/vacuole for degradation. During macroautophagy, the sequestering vesicles, termed autophagosomes, fuse with the lysosome or vacuole resulting in the delivery of an inner vesicle (autophagic body) into the lumen of the degradative compartment. There are 16 proteins participating in the autophagy pathway in human. The autophagy protein LC3, a mammalian homologue of Atg8, was originally identified as microtubule-associated protein 1 light chain 3. It is a component of both the MAP1A and MAP1B microtubule-binding domains and the heavy-chain independent regulation of LC3 expression might modify MAP1 microtubule-binding activity during development. LC3 is the only known mammalian protein identified that stably associate with the autophagosome membranes. LC3-I is cytosolic and LC3-II is membrane bound and enriched in the autophagic vacuole fraction. The detection of LC3-I to LC3-II conversion is a useful and sensitive marker for distinguishing autophagy in mammalian cells.

Type: Primary
Antigen: LC3A/B
Clonality: Polyclonal
Clone:
Conjugation: Unconjugated
Epitope:
Host: Rabbit
Isotype: IgG
Reactivity: Rat, Zebrafish, Mouse, Human, Canine



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TECHNISCHE DATEN

Antigen symbol LC3A/B
Antigen name Microtubule-associated Protein 1 light chain 3 alpha And beta
Reaktivität Mouse, Dog, Human, Zebrafish, Rat
Konjugation Unconjugated
Klonalität Polyclonal
Antikörper Typ Primary
Wirt Rabbit
Isotyp IgG
Western Blot Yes
ELISA Yes
ImmunoChemistry Yes
ImmunoPrecipitation Yes
ImmunoFluorescence Yes
Flow Cytometry Yes
Antigen synonyms MAP1A/MAP1B LC3, Microtubule-associated proteins 1A/1B light chain 3B, MAP1LC3, MAP1LC3B, Microtubule-associated proteins 1A/1B light chain, MAP1LC3A, map1lc3a, MAP1 light chain 3-like protein 1, MAP1 light chain 3-like protein 2, LC3
Gene ID 84557, 362245, 64862, 67443, 81631, 66734, 406466
Konzentration 1 mg/ml
Immunogen Synthetic peptide corresponding to a region between residues 25-121 of human LC3 protein.
Purification Antigen affinity chromatography
Form Liquid
Storage Buffer PBS, 0.02% sodium azide
Lagertemperatur -20°C or -80°C if preferred
Transporttemperatur Ice
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