The PATHO-GENE® HPV screening probe is a mixture of biotin-labeled HPV 6, HPV 11, HPV16, HPV 18, HPV 31, HPV 33, and HPV 51-specific probes in buffered formamide and hybridisation enhancers.
PATHO-GENE® HPV screening probe employs a mixture of the HPV-specific probes that have been specificallly formulated to detect most HPV types that have been associated with anogenital papillomas. Among the HPV types detected with the PATHO-GENE® HPV screening probes are those commonly associated with benign lesions presenting as condylomas and mild dysplasia, as well as types commonly associated with cervical intraepithelial neoplasia (CIN) and carcinoma in situ (CIS). The PATHO-GENE® HPV screening probe detects but does not distinguish among HPV types that have shown to be associated with sexually transmitted papillomavirus. The probe mixture is denatured and hybridised to the tissue section fixed and pretreated on the microscope slide. Specific hybridisation between the HPV DNA probe and DNA in the specimen is determined by the detection of biotin.
