Y-27632 (hydrochloride)Lieferant: Cayman Chemical
CAYM10005583-50EA 852 EURCAYM10005583-50 CAYM10005583-1 CAYM10005583-10 CAYM10005583-5
Y-27632 is a potent, ATP-competitive inhibitor of ROCKs including p160ROCK (Ki = 140 nm) and ROCK-II (IC50 = 800 nm). It also inhibits PRK2 with an IC50 value of 600 nm.
- Crystalline solid
- Purity ≥98%
- Storage at −20 °C
One-hour treatment with 10 µm Y-27632 blocks apoptosis of dissociated cultured human embryonic stem cells, increasing cloning efficiency by 25% and sustaining survival up to 30 passage.