Rosiglitazone ≥98%

Lieferant: Cayman Chemical

CAYM71740-100EA 239 EUR
CAYM71740-100 CAYM71740-25 CAYM71740-10 CAYM71740-50
Rosiglitazone ≥98%

Thiazolidinediones (TZDs) are a group of structurally related peroxisome proliferator-activated receptor γ (PPARγ) agonists with antidiabetic actions in vivo. Rosiglitazone is a prototypical TZD and has served as a reference compound for this class. Rosiglitazone is a potent and selective PPARγ ligand. It binds to the PPARγ ligand-binding domain with a Kd of 43 nM. It activates luciferase-based expression constructs PPARγ1 and PPARγ2 with EC50 values of approximately 30 nM and 100 nM, respectively. Rosiglitazone is active in vivo as an antidiabetic agent in the ob/ob mouse model, and has been used as an oral hypoglycemic agent in the treatment of Type II diabetes in humans for many years.

Formel: C₁₈H₁₉N₃O₃S
Molekulargewicht: 357,43 g/mol
MDL Number: MFCD00871760
CAS-Nummer: 122320-73-4


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