Gestrinone ≥98%, kristalliner Feststoff
Lieferant: Cayman Chemical
Gestrinone is a synthetic steroid used occasionally to treat endometriosis.
Endometriosis is common disease characterised by the presence of endometrial tissue outside the uterus which affects approximately 10% of premenopausal women. Gestrinone acts centrally on the hypothalamic-pituitary system to suppress release of lutenizing hormone (LH) and follicle-stimulating hormone (FSH), thus reducing estrogen synthesis. It also binds to androgen (AR), progesterone (PR), and estrogen (ER) receptors in the human endometrial tissue but not to steroid hormone binding globulin or corticord-binding globulin. Gestrinone binds to AR and PR with EC50 values of approximately 20 and 30 nM, respectively. These values reflect approximately 5 – 6 fold lower affinity than testosterone and progesterone, the natural AR and PR ligands, for these receptors.
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Formel:
C₂₁H₂₄O₂ Molekulargewicht: 308,42 g/mol |
MDL Number:
MFCD00865561 CAS-Nummer: 16320-04-0 |
Spezifikation Testergebnisse
| Purity | ≥98% |
| Formulation | Crystalline solid |
| λmax | 238, 341 nm |
| Storage | −20 °C |
| Stability | ≥2 years |
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